老年急性白血病医院感染的临床特点分析

Hospital Infection in Senile Patients with Acute Leukemia: A Clinical Analysis

目的探讨老年急性白血病患者医院感染的临床特点。方法对我院10年间62例老年急性白血病患者医院感染发生率、感染部位、致病菌和易感因素等进行回顾性分析,并与同期非老年组进行比较。结果老年组发生医院感染率为72.5%,高于同期非老年组的33.9%,P<0.01;感染部位以口腔和呼吸系统多见;多部位感染、重症感染高于非老年组;致病菌以革兰阴性杆菌为主;骨髓抑制、粒细胞缺乏者感染率明显增高。结论老年急性白血病患者医院感染发生率高,骨髓抑制、粒细胞缺乏为主要易感因素,治疗应及时应用有效抗生素,加强综合支持治疗。

OBJECTIVE To investigate the clinical features of the hospital infection in the senile patients with ~acute leukemia. METHODS The hospital infection rate, the infective sites, the pathogenic bacteria and the ~infectious factors of 62 senile acute leukemia patients during the past 10 years were analyzed retrospectively, and ~compared with groups of non-senile patients in the corresponding period. RESULTS The incidence of the hospital infection in the senile patients (72.5%) was higher than that of non-senile ones (33.9%), P<0.01. The most commonly infective sites were oral cavity and respiratory system. The multiple and serious infection in the senile patients was more than that of non-senile ones. The common pathogenic bacteria were mainly Gram-negative one. There was a markedly higher infection rate in bone merrow inhibition and agranulocytosis patients. ~CONCLUSIONS The hospital infection incidence of senile patients with acute leukemia is higher. The main infectious ~factor is bone merrow inhibition.