新一代喹诺酮类药物NM394的合成

Synthesis of new fluroquinolone NM394

目的:合成新一代喹诺酮类药物NM394.方法:以3,4-二氟苯胺为原料,经过成盐、缩合、亲核加成、乙基化、热环合、羟基保护、氯代、脱氯化氢和脱保护基与哌嗪缩合后水解得目标化合物.结果和讨论:经IR,1H-NMR,MS证明得到了NM394;在制备化合物3和8时,改进了工艺,提高了产率.

Objective: To synthesize the new generation of fluroquinolone drug NM349. Methods:NM394 was prepared via 11 steps using 3, 4-difluoroanilin as a starting material. Results: The chemical structure of the NM394 was confirmed by IR, MS, and ~1H-NMR. Conclusion:The modification of a few steps in the synthesis can simplify the procedure and increase the yields.