环境接触青石棉与胃肠道肿瘤发病危险的队列研究

A RESTROSPECTIVE COHORT STUDY OF THE RISK OF GASTROINTESTINAL CANCER RELATION TO ENVIRONMENTAL CROCIDOLITE EXPOSURE

目的 :了解环境接触青石棉的人群患胃肠道肿瘤的危险。方法 :采用回顾性队列调查研究方法 ,计算接触青石棉人群胃肠道肿瘤的死亡率和相对危险度 (RR)。结果 :15年观察队列中恶性肿瘤死亡 186人 ,其中胃癌和肠癌各 15例 ,死亡率均为 174 2 /10 6人年。两组的胃癌死亡率差异无显著性 (χ2 =0 2 35 ,P >0 0 5 )。观察组与对照组比较患肠癌的RR为 1 4 94 ,差异无显著性 (χ2 =0 919,P >0 0 5 ) ,但在观察组男性中患肠癌的RR值为 3 78,与对照组相比 ,差异有显著性 (χ2 =4 986 ,P <0 0 5 )。结论 :环境接触青石棉后可能会增大男性肠癌发病的危险。

Objective:To explore the risk of gastrointestinal cancer in group exposed to environmental crocidolite pollution.Methods:A retrospective cohort study was carried out, The relative risk and mortality of gastrointestinal cancer in the group exposed to environmental crocidolite pollution was computed.Results:There are 186 cases died of malignant cancer in the 15-years cohort, including 15 cases of gastric cancer and 15 cases of intestinal cancer, the mortalities are both 174.2/10 6 person-year respectively. There is no significant difference in mortality of gastric cancer between the case group and the control group(χ 2=0.235,P>0.05).Compared with the control group,the case group's relative risk of intestinal cancer is 1.494,the difference is no significance (χ 2=0.919,P>0.05);while the male's RR is 3.78,the difference is evidently significant(χ 2=4.986,P<0.05).Conclusion: The increased risk of male intestinal cancer may be related to the environmental crocidolite exposure. And the environmental crocidolite exposure may not increase the mortality of gastric cancer.