期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

脂肪分布与胰岛素抵抗 被引量：1

Relationship between body fat distribution and insulin resistance
下载PDF
导出
摘要 身体的脂肪分布与胰岛素敏感性相关。不同部位的皮下及肝脏、肌细胞间、肌细胞内的脂肪储积分别与不同程度的胰岛素抵抗相关。不同部位脂肪组织的胰岛素抵抗相关基因及其表达的差异 ,提示在不同部位脂肪组织之间有着内在的生物学差别。 Body fat distribution is associated with insulin sensitivity.Region specific subcutaneous,liver,intramuscular,and intramyocellular lipid deposition is responsible for insulin resistance in various degree.It is the differential expression of the regional adipose tissue genes relating with insulin resistance that indicates the fats in various region are intrinsically biologically distinct.
作者 邵致格 孙桂菊 胡曼菁
机构地区 东南大学医学院中医科
出处 《现代医学》 2005年第1期63-66,共4页 Modern Medical Journal
关键词 胰岛素抵抗 脂肪分布 脂肪组织 肌细胞 皮下 胰岛素敏感性 相关基因 生物学 差异 提示 body fat distribution insulin resistance gene expression profiling
分类号 R587 [医药卫生—内分泌] R589.2 [医药卫生—内分泌]
  • 相关文献

参考文献17

  • 1JOHNSON J A, FRIED S K, PI-SUNYER FX, et al. Impaired insulin action in subcutaneous adipocytes from women with visceral obesity[J]. Am J Physiol Endocrinol Metab, 2001,280: E4O-49.
  • 2MIYAZAKI Y, GLASS L, TRIPLITF C, et al. Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus[J]. Am J Physiol Endocrinol Metab, 2002,283 : E1135-1143.
  • 3WILLNER I R,WATERS B,PATIL S R,et al. Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease [J]. Am J Gastroenterol, 2001,96 : 2957-2961.
  • 4TIIKKAINEN M, TAMMlNEN M, HAKKINEN A M, et al. Liver fat accumulation and insulin resistance in obese women with prfivious gestational diabetes [J]. Obes Res, 2002,10: 859-867.
  • 5TIIKKAINEN M, BERGH 3LM R, VEHKAVAARA S, et al. Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content[ J]. Diabetes, 2003,52 : 701-707.
  • 6SEPPALA-LINDROOS A, VEHK VAARA S, HAKKINEN A M, et al. Fat accumulation in the hver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men [J]. J Clin Endocrinol Metab,2002,87 : 3023-3028.
  • 7GOODPASTER B, KELLY D. Significance of thigh tissue compartmentalization in insulin resistance [J]. Diabetes, 1998, 47: A315:1220.
  • 8GOODPASTER B, HE J. Excessive lipid accumutation within skeletal muscle fiber is assciated with insulin resistance [J]. Diabetes, 2000,49: A28.
  • 9GOODPASIER B H,THAETE F L, KELLY D E. Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus[J] .Am J Clin Nutr,2000,71:885-892.
  • 10THEERIAULT R, GOODPASTER B, KELLY D. Intramuscular hpid content quantified by histochemistry is increased in obesity and type 2 diabetes mellitus[J]. Diabetes, 1998,47:A315: 1221.

同被引文献1

引证文献1

二级引证文献6

现代医学
2005年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部