血管生成素在人口腔鳞癌的表达及意义

Expression and Significance of Angiopoietins in Oral Squamous Cell Carcinoma

目的 研究血管生成素(Ang)家族中Ang_1、Ang_2蛋白在口腔鳞癌组织中的表达,并探讨其与口腔鳞癌病 理分级的关系。方法 采用免疫组化SABC方法,检测34例口腔鳞癌组织及16例正常口腔黏膜组织中Ang_1和 Ang_2蛋白的表达。结果 Ang_1、Ang_2蛋白在口腔鳞癌细胞均有表达。Ang_1在正常口腔黏膜和口腔鳞癌组织及 各级口腔鳞癌中表达,无明显差异(P>0.05);Ang_2在口腔鳞癌组织的表达明显高于正常口腔黏膜(P<0.05),且 Ang_2的表达随口腔鳞癌分级的增加而逐渐增强(P<0.05)。结论 Ang_2在口腔鳞癌组织中的表达明显上调,并 随着肿瘤恶性程度的增高表达水平升高。作为肿瘤血管新生的标志之一,可能与口腔鳞癌的血管生成和早期转移 有关。

Objective To observe the expression of angiopoietins in oral squamous cell carcinoma and relationship between the expression of angiopoietins and pathologic classification.Methods The expression of Ang-1 and Ang-2 protein in samples from 42 oral squamous cell carcinoma and 16 oral normal mucosa were detected by immunohistochemical technique.Results The expression of Ang-1 and Ang-2 was found in both oral squamous cell carcinoma and normal control. It was found Ang-1 expression alike in oral squamous cell carcinoma and control (P>0.05). Ang-2 expressed at low level in control while strongly positive in oral squamous cell caroinoma and the level of Ang-2 expression in oral squamous cell caroinoma was related to pathologic classification (P<0.05).Conclusion Ang-2 expression in oral squamous cell carcinoma is related to angiogenesis and pathological classification, which is probably involved in angiogenesis regulation, promotes the development and metastasis of oral squamous cell carcinoma.