高果糖饲料诱导SD大鼠氧化应激及对其脂质代谢的影响

Oxidative Stress Induced by High-fructose Diet and its Effects on Lipid Metabolism of SD Rats

目的探讨高果糖饲料诱导SD大鼠氧化应激和对其脂质代谢的影响。方法实验大鼠分为2组熏分别用普通饲料和高果糖饲料喂养8周,检测大鼠空腹血糖(FBG)、血胰岛素(FSI)、血脂、总抗氧化力(T鄄AOC)、丙二醛(MDA)及超氧化物岐化酶(SOD)等。结果高果糖饲料组胰岛素敏感指数(ISI)低于普通饲料组(P<0.01),甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL鄄C)升高(分别为P<0.01,P<0.05和P<0.01),高密度脂蛋白胆固醇(HDL鄄C)降低(P<0.05),T鄄AOC、SOD活性降低(P<0.01),MDA水平升高(P<0.01)。结论高果糖饲料可诱导SD大鼠产生氧化应激,引起脂质代谢紊乱。

Objective To study oxidative stress induced by high-fructose diet and its effects on lipid metabolism of SD rats. Methods The rats were divided into two groups, one fed with basic diet and the other with high-fructose diet. At the end of 8th week, their blood samples were collected and contents of FBS, FSI, blood lipids, T-AOC, MDA and SOD were determined and ISI was calculated. Results Compared with basic diet group, the ISI and the levels of HDLC and T-AOC and the activity of SOD in high-fructose diet group decreased significantly (P<0.05 or P<0.01), while the levels of TG, TC, LDLC and MDA increased significantly (P<0.05 or P<0.01). Conclusion High-fructose diet induced oxidative stress and caused the disorders of lipid metabolism of SD rats.