1Hoyer S. ls sporadic Alzheimer disease the brain typer of noninsulin dependent diabetes mellitus? A challenging hypothesis.J Neural Transm, 1998, 105:415-122.
2Gispen WH, Biessels G J, Cognition and synaptic plasticity in diabetes mellitus. Trends Neurosci, 2000, 23:542-549.
3Leisson CL, Rocca WA, Hanson VA, et al. Risk of dementia among persons with diabetes mellitus: a population-based cohort study, Am J Epidemiol, 1997, 145:301-308.
4Rasgon N, Jarvik L. lnsulin resistance, affective disorders,and alzheimer's disease: review and hypothesis. J Gerontol A Biol Sci Med Sci, 2004, 59:178-183.
5Peyrot M, Rubin RR. Levels and risks of depression and anxiety symptomatology among diabetic adults. Diabetes Care,1997, 20:585-590.
6Okamura F, Tashiro A, Utumi A, et al. insulin resistance in patients with depression and its changes during the clinical course of depression: minimal model analysis. Metabolism,2000, 49:1255-1260.
7Craft S, Newcomer J, Kanne S, et al, Memory improvement following induced hyperinsulinemia in Alzheimer's disease.Neurobiol Aging, 1996, 17 : 123- 130.
8Vanhanen M. Soininen H, Glucose intolerance, cognitive impairment and Alzheimer's disease. Curr Opin Neurol, 1998,11:673-677.
9Gasparini L, Netzer WJ, Greengard P, et al. Does insulin dysfunction play a role in Alzheimer's disease? Trends Pharmacol Sci, 2002, 23:288-293.
10Caraft S, Asthana S, Schellenberg G, et al. Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E genotype and gender. Neuroendocrinology, 1999, 70:146-152.
6Lu Y, Hao H, Liu GQ. Advances on P-glycoprotein at Blood-brain Barrier[J]. Neurosci Bull. 2005, 21 (5) : 351 -3.
7Liu HY, Xu X, Yang JH et al. Impaired function and expression of P-glycoprotein in blood-brain barrier of streptozotocin-induced diabetic rats[J].Brain Res. 2006, 1123 : 245 - 52.
8Hao Hong, Lu Y, Ji ZN, et al. Up-regulation of P-glycoprotein expression by glutathione depletion-induced oxidative stress in rat brain microvessel endothelial cells[ J ]. J Neurochem,2006,98 (5) : 1465 - 3.
9Pick E. Microassays for superoxide and hydrogen peroxide production and nitroblue tetrazolium reduction using an enzyme immunoassay microplate reader[ J]. Methods Enzymol, 1986,132:407 - 21.
10Cirrito JR, Deane R, Fagan AM, et al. P-glycoprotein deficiency at the blood-brain barrier increases amyloid - beta deposition in an Alzheimer disease mouse model [J].J Clin Invest,2005,115 (11 ): 3285 - 90.