加兰他敏乳膏体外透皮吸收实验研究

Study on in Vitro Percutaneous Absorption of Galanthamine Cream

目的 :考察加兰他敏乳膏的体外透皮吸收效果。方法 :采用小鼠离体皮肤作为渗透屏障 ,研究不同浓度氮酮对加兰他敏促渗作用的影响。结果 :氮酮可显著提高加兰他敏皮肤渗透作用 ,含2 %和5 %氮酮的乳膏稳态流量比不含氮酮的乳膏分别增加56 12 %和23 29 %。结论 :加兰他敏乳膏具有良好的皮肤渗透性 ,且以含2 %氮酮的乳膏促渗效果最好。

OBJECTIVE:To study the in vitro percutaneous permeability of galanthamine cream.METHODS:Using isoˉlated mouse's skin as barrier to permeation,the promoting effect of azone in different concentrations on permeation of galanth_ amine was studied.RESULTS:Azone could obviously enhence the permeability of galanthamine through skin.The steady flux of galanthamine cream containing2%and5%azone increased56.12%and23.29%respectively.CONCLUSION:Galanthamine cream has good percutaneous permeability and2%azone promotes the permeability best.