槲皮素-聚维酮固体分散体中槲皮素的含量测定

Determination of the Content of Quercetin in Quercetin-PVP Solid Dispersions

目的 :建立槲皮素 -聚维酮固体分散体中槲皮素的含量测定方法。方法 :于槲皮素特征吸收峰374nm波长处测定其含量。结果 :槲皮素浓度在5 0～25 0μg/ml范围内线性关系良好 ,r=0 9998 ,平均回收率为99 12 %,RSD=0 70 %(n=6)。结论 :本方法稳定、快速、准确、简便 ,可为制备槲皮素 -聚维酮固体分散体提供质量控制手段。

OBJECTIVE:To establish a method for determination of the content of quercetin in quercetin-PVP solid disˉpersions.METHODS:The detection wavelength for dertermination of quercetin content was set at374nm.RESULTS:The caliberation curve was linear in the range of5.0～25.0μg/ml(r=0.9998).The average recovery was99.12%,RSD=0.70%(n=6).CONCLUSION:This method is stable,quick,accurate and simple,and is suitable for quality control of quercetin in quercetin-PVP solid dispersions.