苦地丁对小鼠免疫功能影响的实验研究

Experimental study of effect of Corydalis Bengeana Tures on immunologic function of mice

目的探讨苦地丁对小鼠免疫功能的影响。方法实验组小鼠灌胃给苦地丁水煎剂(0．2g／ml)，每次0．5ml，每日1次；对照组小鼠灌胃给同等量生理盐水；7d后两组小鼠同时测定脾、胸腺重量，腹腔巨噬细胞吞噬功能，脾淋巴细胞增殖反应及IL-2活性。结果苦地丁可使脾和胸腺萎缩，巨噬细胞吞噬功能降低，淋巴细胞增殖反应受到抑制，IL-2活性减弱，与对照组比较具有非常显著性差异(P＜0．01)。结论苦地丁对小鼠免疫功能有明显的抑制作用。

Objective To investigate the effect of Corydalis Bengeana Tures on immunologic function of mice.Methods The administration of decoction of Corydalis Bengeana Tures(0.2 g/ml) was through perfusion into the stomach of mice with 0.5 ml each time and once a day while the same amount of saline was given in the confrol group.and 7 day later,the weight of spleen and chest gland,macrophage phagocytic function of the abdomen,splenic lymphocytic proliferation and IL-2 activity were respectively determined in both groups.Results Corydalis Bengeana Tures could cause atrophy of spleen and chest gland,decrease of macrophage phagocytic function,inhibition of splenic lymphocytic proliferation and reduction of IL-2 activity,thus there was significant difference in comparison with the control group(P<0.01).Conclusion Corydalis Bengeana Tures has a significant inhibiting effect on the immunologic function of mice.