血浆肾素活性与血管紧张素Ⅱ对心衰疗效判定

Therapeutic evaluation of PRA and AII in CHF treatment

目的：探讨血浆肾素活性(PRA)与血管紧张素Ⅱ(AⅡ)对卡托普利(CPT)治疗充血性心力衰竭(简称心衰)的疗效判定价值。方法：30例心衰患者分为CPT治疗组(16例)和心衰对照组(14例)，在治疗前及治疗后28d分别抽血检测PRA与AⅡ。结果：CPT组AⅡ在治疗后明显降低(P<0．01)，PRA在治疗后显著升高(P<0.01)；心衰对照组AⅡ及PRA在治疗前后无显著改变。结论：应用CPT治疗心衰具有良好的临床效果，监测血浆PRA与AⅡ含量对于判定血管紧张素转换酶抑制剂(ACⅡ)类药物疗效及愈后具有一定的临床意义。

Objective: To evaluate the effect of PRA and AⅡ in CHF treatment by CPT. Methods: Thirty cases with CHF were dovided into two groups:16 cases in CPT and 14 cases in control group.PRA and AⅡ were detected respectively before treatment and on the 28th day after treatment. Results: In CPT treatment group AⅡ level decreased obviously ( P < 0.01 )while PRA level significantly increased after treatment.But in the control group there was no such changes. Conclusion: CPT has a better clinic therapeutic e...