女性胆囊结石患者垂体-性腺激素和胆固醇水平关系探讨

Relationship Between Pituitary-Gonadal Hormone and Cholesterol Level in Female Patients with Gallbladder Stones

本文报道32例女性胆囊结石(A组)和25例非胆囊结石(B组)女性患者垂体一性腺激素和外周血、门静脉血、胆汁三种体液胆固醇水平研究。结果 A 组 FSH,LH、P_4、胆汁 TC 明显高于 B 组(P<0.01),A 组胆汁 TC 高于门静脉血和外周血(P<0.01),孕龄期E_2 A 组低于 B 组,绝经期 E_2 A 组高于 B 组。P_4A 组均高于 B 组。研究表明胆囊结石与性腺内分泌功能失调有关,雌性激索水平变化与胆汁胆固醇过饱和有关。

The levels of pltuitary-gonadal hormones and cholesterols of the peripheral blood,portal vien blood,bile were studied in 32 women with gallstones(group A)and 25 with-out gallstones(group B).The results showed:group A was obviously higher than groupB in follicularstimulating hormones(FSH),luteinizing hormones(LH)and progester-one(P4)(P<0.01).The cholesterol content in bile was significantly higher than chol-esterol in portal vien and peripheral blood in group A(P<0.01).Group A was lowerthan group B with levels of estradiol in reproductive-aged women and group A washigher than group B in postmenopausal women,group A was higher than group B withlevels of P4 in both reproductive-aged women and postmenopausal women.It wasfound that the gallstones formation in women was related to the dysfunction of pi-tuitary-gonadal hormone,and changes of gonadal levels was related to increased cho-lesterol contents in bile.