115例习惯性流产病因分析

Etiologic Analysis of 115 Cases of Habitual Abortion

分析了115例习惯性流产病例,占同期自然流产病例的9.5%(115/1213)。习惯性流产常见病因有;免疫因素(ABO 抗原、自身抗体)、子宫颈机能不全、黄体功能不良、子宫因素(子宫畸形、子宫肌瘤),染色体异常和精子异常等,以 ABO 抗原导致流产居首位。分析表明:母儿间 ABO 抗原不相容是导致习惯性流产的重要因素之一。此外,自身免疫性疾病或自身抗体(抗磷脂抗体)阳性在导致习惯性流产中占一定比例。习惯性流产以流产三次者发病最多(占49.6%),早期流产明显多于中期。

The causes of 115 cases of habitual abortion were studied.Among abortions inthe same period,habitual abortions were accounted for 9.5%(115/1273).The commoncauses of habitual abortion were immunological factors(ABO-incompatibility andlupus anticoagulant),incompetent cervix,luteal phase defects,uterine factors(uterinemalformation,uterine myoma),abnormal chromosomes and sperms,etc.The result revealed the most important factor of habitual abortion was the ABO-incompatibility.And then,autoimmune diseases or positive lupus anticoagulant took visible proportion in the causes of abortion.First trimester abortions were more thanthose in the mid-pregnancy.