IP方案治疗35例复发和难治性非霍奇金淋巴瘤疗效分析

Effect of IP regimen on recurrent and refractory non-Hodgkin's lymphoma

目的:观察IP方案治疗复发和难治性非霍奇金淋巴瘤的疗效和毒性反应.方法:对35例复发和难治性非霍奇金淋巴瘤患者采用IFO 1.5 g/m 2,静滴,第1～5天; Mesna 0.4 g,静注,于IFO静滴后0.4 h各1次,第1～5天; DDP 30 mg/m 2,静滴,第1～3天.以上方案每3～4周重复1次,连用2～3个周期.结果:全组35例,CR 5例,PR 23例,总有效率80.0%.毒副反应主要是血液学毒性,白细胞和血小板下降发生率分别为77.1%、34.3%,白细胞Ⅲ、Ⅳ度毒性为25.7%、11.4%.结论:IP 方案治疗复发和难治性非霍奇金淋巴瘤的疗效比较满意,其毒性能够耐受,经对症处理均能恢复.

Objective: To observe the effect and side effects of IP regimen for patients with recurrent and refractory Non-Hodgkin's lymphoma. Methods: 1.5g/m+2 Ifosfamide (IFO) was administered iv by drop on d 1~5; Mesna 0.4 g,iv at 0、4 hour after the administration of IFO on d1~5; 30 mg/m+2 cisplatin iv by drop on d1~3. Results: In all 35 patients, 5 CR and 23 PR, 80% of response rate was achieved. Main toxicities were neutropenia and thrombocytopenia with occurrence rate of 77.1%、34.3% respectively,Ⅲ or Ⅳ degree neutropenia were 25.7% and 11.4%. Conclusion: IP regimen can achieve a satisfied results in the treatment of recurrent and refractory Non-Hodgkin's lymphoma with well tolerated toxicity.