摘要
以非崩解型溶出度校正片水杨酸片和布洛芬缓释胶囊为模型药物,考察中外药典不同取样位置对药物溶出度测定的影响。两种方法所得溶出曲线经威布尔(Weibull)分布模型拟合,水杨酸片、布洛芬缓释胶囊的AUC、Td和T50等均无显著性差异(P>0.05)。
Effect of different sampling positions, the methods as prescribed in USP and Ch.P., on dissolution test was discussed. Salicylic acid tablets (dissolution calibrator, nondisintegrating) and ibuprofen sustained-release capsules were used as models. The dissolution curves were fitted with the Weibull distribution model. The results showed that the parameters of AUC, Td and T50 had no significant difference between two methods (P>0.05).
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2005年第2期91-92,共2页
Chinese Journal of Pharmaceuticals
关键词
水杨酸片
布洛芬缓释胶囊
取样位置
溶出度:Weibull分布模型
salicylic acid tablets
ibuprofen sustained-release capsules
sampling positions
dissolution test
Weibull distribution model
