原发性肝癌根治术后复发因素分析

Analysis of Intrahepatic Recurrence Factors after Resection of Primary Hepatocellular Carcinoma

对64例肝癌根治术后随访10年以上患者,分复发、长期生存两组进行了临床和病理特征比较分析。结果表明,术后复发率为59.38％(38/64),其中1、3、5、10年复发率分别占17.19％、35.94％、46.88％和53.13％。并提示有症状就诊患者、瘤肿纤维包膜不完整或无包膜、伴中或重度肝硬变、有明显的肝细胞不典型增生变、肉眼不易发现的血管内癌栓以及HBsAg、HBcAg同时出现在癌周肝内的HBV复制,是肝癌根治术后复发的主要因素。

Comparative analysis of clinical and pathological characteristics was undertaken in 64 patients who had been under follow-up over 10 years after resection of hepatocell- ular carcinoma. The patients were divided into two groups, one group had intrahepatic recurrence after operation and another group of patients who survived over 10 years and had no intrahepatic recurrence. The results indicated that the recurrence rate of intrahepatic carcinoma after operation was 59.38％(38/64), the rates after 1, 3, 5, 10 years were 17.19％, 35.94％, 46.88％ and 53.13％ respectively. It suggested that having had symptoms on admission, peritumor fibrous encapsulation absent or uncomplete, moderate or serious hepatic cirrhosis, atypical hepatocellular hyperplasia, cancerous embolism in blood vessel which could be found uneasily by eye and HBV replication in liver(HBsAg. HBcAg co-exist) were main factors of recurrence after resection of hepatocellular carcinoma.