原发性进行性失语综合征1例报告(英文)

One case of primary progressive aphasia syndrome

背景:原发性进行性失语综合征是一种少见类型的痴呆综合征,国内报道较少。目的:报告1例发生在中国的以非流利型失语为主要临床表现的原发性进行性失语综合征患者。设计:以患者为研究对象,观察性研究,病例分析。单位:一所大学医院和一所军区总医院的神经科。对象:患者,男性,64岁,右利手,于2002-04哈尔滨医科大学第一临床医学院入院。方法:患者进行了神经心理学检查、头部组织成像检查(CT和MRI)和功能成像检查犤单光子发射计算机断层脑显像(SPECT)犦。主要观察指标:①神经心理学检查结果。②影像学检查结果。结果:神经心理学检查显示为非流利型失语,以命名不能为首发症状。CT和MRI示“左侧半球颞叶萎缩,外侧裂周围区域增宽”,SPECT示“左侧颞叶、额叶及部分顶叶血流灌注降低”。结论:患者的临床表现、神经心理学和神经影像学检查结果支持原发性进行性失语综合征的诊断。

BACKGROUND:Primary progressive aphasia syndrome(PPA) is an unusual type of dementia,and the relevant reports are very rare in China. OBJECTIVE:To describe a Chinese PPA patient with non fluent aphasia as the main clinical characteristic. DESIGN:An observed trial and a case analysis based on patients. SETTING:Department of Neurology in a hospital of a university and a general hospital of a military area command of Chinese PLA. PARTICIPANT:The patient was a 64 year old and right handed man,who hospitalizated in First Clinical Medical College,Harbin Medical University in April 2002. METHODS:Neuropsychological assessment,head structural computed tomograph and magnetic resonance imaging and functional single photon emission computed tomography(SPECT) imaging were used in this patient. MAIN OUTCOME MEASURES:①neuropsychological results;②imaging results. RESULTS:Neuropsychological testing revealed predominantly non fluent aphasia,anomia was the earliest symptom.CT scan and MRI revealed atrophy of left temporal convexities and enlarged sylvian fissures.SPECT exhibited hypoperfusion in the left temporal, frontal,and partially parietal areas. CONCLUSION:The clinical symptoms,the neuropsychological and neuroimaging findings fit the diagnosis of PPA.