血管内皮生长因子及其对成骨的影响(英文)

Vascular endothelial growth factor and its effect on bone formation

目的:综述有关血管内皮细胞生长因子(vascularendothelialgrowthfac-tor,VEGF)的实验结果及其对成骨的影响,明确VEGF是否能促进骨的形成。资料来源:资料来源于http://www.ncbi.nlm.nih.gov/pubmed和http://www.zglckf.com数据库等相关网站,采取电子数据检索方式获得。资料选择:选择有关VEGF的文章以及VEGF影响成骨的文章近30篇。不考虑文章中是否应用随机设计、盲法。数据提炼:这些研究证实了VEGF和VEGF受体的结构、生物学特性、表达。提示VEGF通过促进新生血管的形成、加快骨转换和阻止软骨细胞凋亡在软骨内成骨中扮演重要角色。膜内成骨中,在无软骨出现的情况下,成骨细胞产生、应答VEGF。VEGF激活、趋化破骨细胞,同时趋化、分化成骨细胞和促进基质的矿化。目前关于局部单纯应用外源性VEGF能否促进成骨仍有争论。但在某些情况如局部缺血环境下,增加局部VEGF可促进成骨。资料综合:与对照组相比,VEGF能通过对软骨内成骨、膜内成骨的影响促进骨的发生、形成和改建。结论:局部VEGF治疗的优势在于其既可刺激血管形成又可促进骨的形成和改建。如果最终能应用VEGF的这些特性治疗缺血性骨坏死、骨缺损、骨不连等疾病,将发现一条新的治疗途径。

OBJECTIVE:To review the outcomes of experiments about vascular endothelial gro wth factor(VEGF)and the effect of it on bone formation,and to make sure whether VEGF can promote bone formation or not. DATA SOURCES:Electronic data searches were performed to obtain data from the d atabases of http://www.ncbi.nlm.nih.gov/pubmed and http://www.zglckf.com. DATA SELECTION:Nearly 30 articles about VEGF and the role of VEGF affecting bo ne formation were selected,regardless of the randomized design,blind method invo lved in or not. DATA EXTRACTION:These researches proved the structures,biologic properties and expression of VEGF and vascular endothelial growth factor receptor(VEGFR),and s howed that VEGF plays an important role in endochondral ossification by promotin g angiogenesis,bone turnover and preventing apoptosis of chondrocyte.In intramem branous ossification,absence of cartilage,osteoblasts are likely producing,and r esponding to,VEGF.VEGF also acts to recruit and activate osteoclasts as well as stimulate osteoblast chemotaxis,differentiation and matrix mineralization.It is debatable whether local application of exogenous VEGF can promote bone repair or not.However,in certain situation such as ischemia,the increase of VEGF locally may promote bone repair. DATA SYNTHESIS:Compared with the control group,VEGF can promote osteogenesis,b one formation and remodeling through the effect of VEGF on endochondral ossifica tion and intramembranous ossification. CONCLUSION:One possible advantage of local VEGF therapy may be its ability to couple angiogenesis with bone formation and remodeling.If we can ultimately appl y VEGF to treat osteonecrosis,bone defect and nonunion,we will find a new therap y for these diseases.