人参皂苷对动物脑神经保护作用及其机理研究进展

Protective Effect and Mechanism of Ginsenosides on Central Nerve System of Animals

本文就近 10年人参皂苷对脑神经保护作用及其机理的研究概况进行了综述。人参皂苷对正常动物、老年动物和学习记忆障碍模型动物学习记忆功能有改善作用 ;人参皂苷对脑神经保护作用机制涉及钙通道拮抗作用、对谷氨酸和γ 氨基丁酸的影响、抗氧化作用、雌激素样作用、对一氧化氮及一氧化氮合酶的影响、抑制脑神经细胞凋亡、改善线粒体功能障碍等。

Progress of studies concerning the protective effect of ginsenoside on central nerve system (CNS) in animals and its mechanism published in recent decade were reviewed in this paper. It showed that ginsenosides could improve the learning capacity and memory in normal, aged animals, as well as in model animals with impaired memory. The mechanism of the protective effect on CNS involves the effects on calcium channel blockade, glutamate and γ aminobutyric acid, antiperoxidation, estrogen like action, nitric oxide and its synthase, also the inhibition on cerebral nerve cell apoptosis and amelioration on mitochondrial dysfunction, etc.