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对氧磷酶2基因C311S多态性与脑梗死的相关性研究 被引量：9

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摘要 目的探讨对氧磷酶2(paraoxonase2,PON2)基因多态性与脑梗死(cerebralinfarction,CI)的关系。方法用聚合酶链反应限制性片段长度多态性分析法探查PON2基因C311S多态性在脑梗死组、无栓对照组和正常对照组的基因频率。结果发现中国广西人存在PON2基因C311S多态性,C/S等位基因频率为0203/0797。脑梗死组患者PON2基因的C等位基因频率显著高于无栓对照组和正常对照组(P<005)。结论中国人脑梗死患者PON2基因第311位密码子的多态性与脑梗死的遗传学基础有关,C等位基因是动脉粥样硬化性脑梗死的易感基因之一。
作者 赵伟佳 杨和平 沈岳飞 苏承华 林发全 黄春霞 阮立培
机构地区 广西医科大学附属医院神经内科 广西医科大学附属医院检验科 广西医科大学附属医院体检中心
出处 《中国老年学杂志》 CAS CSCD 北大核心 2005年第2期117-119,共3页 Chinese Journal of Gerontology
基金 广西省科学基金资助项目(桂科自:0135008)
关键词 脑梗死 动脉粥样硬化 对氧磷酶2 遗传多态性
分类号 R743 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献10

  • 1张舒凤,孙晓江.对氧磷酶基因(PON1)启动子区T(-107)C多态性与脑梗死的相关性研究[J].中国老年学杂志,2004,24(1):4-6. 被引量：3
  • 2王晓艺,薛耀明,温淑娟,张宁玲,姬仲,潘速跃.对氧磷酶2基因C311S多态性与2型糖尿病合并缺血性脑卒中的相关性[J].中华医学遗传学杂志,2003,20(3):215-219. 被引量：13
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二级参考文献13

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  • 8[8]Oda MN,Bielicki JK,Ho TT,et al.Paraoxonase 1 overexpression in mice and its effect on high-density lipoproteins[J].Biochem Biophys Res Commun,2002;25;290(3):921-927.
  • 9[9]James RW, Leviev I, Ruiz J, et al.Promoter polymorphismsT(-107) C of the paraoxonase PON1 gene is a risk factor for coronary heart disease in type 2 diabetic patients[J].Diabetes,2000;49:1390-1393.
  • 10[10]Leviev I,Righetti A,James RW.Paraoxonase promoter poly-morphism T(-107)C and relative paraoxonase deficiency as determinants of risk of coronary artery disease[J].J Mol Med,2001;79:457-463.

共引文献12

同被引文献123

引证文献9

二级引证文献13

中国老年学杂志
2005年 第2期

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