原发性肝细胞癌中雌激素受体α与β的表达及临床意义

Expression of estrogen receptor α and β in hepatocellular carcinoma and clinical significance

目的 :研究雌激素受体 ( ER) α与 β在原发性肝细胞癌中的表达水平及分布规律。方法 :用免疫组织化学方法检测了 63例原发性肝细胞癌及 63例非肝癌肝组织的 ERα与 ERβ的表达。结果 :原发性肝细胞癌中 ERα与 ERβ的阳性率分别为 2 7% ( Edmondson分级 级的肝癌为 2 3%、 级为 2 8%、 级为 2 9% )和 1 3% ( Edmondson分级 级的肝癌为31 %、 级为 8%、 级为 7% ) ,非肝癌肝组织中 ERα与 ERβ的阳性率分别为 32 % (肝硬化 :30 %、肝海绵状血管瘤 :32 %、正常肝组织 :5 0 % )和 2 9% (肝硬化 :30 %、肝海绵状血管瘤 :2 6%、正常肝组织 :2 5 % )。肝癌与非癌肝组织比较 ERα阳性率无显著差异 ( P>0 .0 5 ) ,但ERβ阳性率有显著意义 ( P<0 .0 5 ) ;Edmondson分级 级的肝癌 ERβ的阳性率与 、 级肝癌比较 ,统计学差异有显著性 ( P<0 .0 5 ) ;肝癌组内 ERα阳性较 ERβ有显著差异 ( P<0 .0 5 )。结论 :原发性肝细胞癌可能具有一定的激素依赖性 ,肝癌的发生、发展及预后可能与ERα的表达无关 ,但与肝癌组织中

Objective: To study the expression and distribution of estrogen receptor(ER) α and β in hepatocellular carcinoma(HCC). Methods: The expression of ERα and ERβ was examined by immunohistochemical methods in 63 cases of HCC and 63 non-HCC cases.Results: The positive rates of ERα and ERβ expression were 27%(Edmondson Ⅰ:23%,Ⅱ∶ 28%,Ⅲ∶ 29%)and 13%(Edmondson Ⅰ∶ 31%,Ⅱ∶ 8%,Ⅲ∶ 7%)in HCC tissues, The positive rates of ERα and ERβ expression were 32%(hepatocirrhosis∶30%,cavernous hemangioma of the liver∶ 32%,normal liver tissues∶ 50%)and 29%(hepatocirrhosis∶30%,cavernous hemangioma of the liver∶ 26%,normal liver tissues∶ 25%)in non-HCC tissues. The expression of ERα showed no significant difference between HCC tissues group and non-HCC tissues group(P>0.05),but ERβ expression in non-HCC tissues is higher than that in HCC tissues(P<0.05). ERβ expression in HCC of Edmondson Ⅰis higher than that in Edmondson Ⅱ,Ⅲ(P<0.05); ERα expression in HCC is higher than ERβ expression in HCC(P<0.05).Conclusions: HCC may be an incretion dependent tumor. The occurrence,development and prognosis of HCC probably do not correlate with the expression of ERα ,but probably has some relationship with reduced quantities of ERβ.