输卵管妊娠患者血清CA_(125)水平及其意义

The level and role of CA_(125) in the pathents' serum of tubal pregnancy

目的探讨CA125在输卵管妊娠患者血清中的变化,与β-HCG的关系及其在预测输卵管妊娠结局中的意义。方法自2002年3月～2003年12月对确诊为输卵管妊娠的78例患者,术前抽取静脉血用放射免疫法检测患者血清中CA125和β-HCG水平,依术中所见和病理诊断将患者分为胚胎存活组、流产组、破裂组,并对结果进行统计分析。结果输卵管妊娠流产组和破裂组的血清CA125均值显著高于存活组(P<001),而流产组与破裂组间的CA125均值无显著差异。用CA125值≥35KU/L判定胚胎发生流产或破裂的灵敏度为823%、特异性为806%。输卵管妊娠患者血CA125值随着血β-HCG水平的降低而增高。结论根据患者临床表现,当患者血清CA125≥35KU/L时有助于诊断输卵管妊娠发生了流产或破裂,补充完善了血β-HCG水平降低在诊断输卵管妊娠胚胎结局中的作用。

Objective:To investigate the level and value of CA_~125 in the pathents' serum of tubal pregnancy , the relation between CA_~125 and β-HCG . Methods:From March 2002 to December 2003,78 patients' serum CA_~125 and β-HCG with tubal pregnancy were examined by radioimmunoassay before operation and then according to the operation and the pathologic diagnosis , the patients were divided into three groups:survival group,abortion group and rupture group. At last the result was analysed statistically.Results:The level of CA_~125 of abortion group and rupture group was much higher than that of survival group (P<0.01),while three was no obvious difference between abortion group and rupture group .According to CA_~125 ≥35KU/L ,the sensitivity of diagnosing abortion or rupture was 82.3%,while peculiarity was 80.6%. The level of CA_~125 will increase with the decrease of β-HCG . Conclusion:According to the patients' symptoms,CA_~125 ≥35 KU/L is helpful to diagnose the tubal pregnancy has aborted or ruptured, of which improves the effect of β-HCG .