嵌段共聚物PDTC-PEG-PDTC的降解和释药性能

In vitro Degradation and Drug Release Properties of Block Copolymers PDTC-PEG-PDTC Prepared by Enzyme

研究了5,5 二甲基 三亚甲基碳酸酯的均聚物(PDTC)及其与聚乙二醇(PEG)组成的嵌段共聚物(PDTC PEG PDTC)的亲水性、水解和酶解性能以及药物释放性能.结果表明:随着聚合物中PEG含量的增加,聚合物的亲水性显著增强;当PEG含量较高时,PEG从聚合物链上断裂溶解使得聚合物的降解速率相对较快;在猪胰脂肪酶(PPL)或假丝酵母皱褶酶(CL)的催化下水解108h,PEG含量对聚合物的水解速率影响不大;药物释放速率随着PEG含量的增大明显提高,n(EO)/n(DTC)为4∶1的嵌段共聚物在30min时释药率高达95%.

The hydrophilicity, hydrolytic and enzymatic degradability, as well as drug-release properties of poly(5,5-dimethyl-trimethylene carbonate)(PDTC) and block copolymers of DTC with PEG (PDTC-PEG-PDTC) were studied. With the increase of content of PEG, the water remaining of PDTC-PEG-PDTC increased. When the content of PEG is high, hydrolytic degradation rate of the copolymer was relatively fast. The introduction of PEG segments to the PDTC main chain didn't significantly alter the enzymatic degradation of PDTC catalyzed by PPL or CL within 108 h. However, increasing the PEG content resulted in the increase of drug release rate, while the drug-release rate could reach 95% within 30 min in the system of copolymer with 4∶1 of n(EO)/n(DTC) in feed.