莲心碱冻干粉针抗心律失常药效学研究

Antiarrhythmic effect of liensinine lyophilization

目的研究莲心碱冻干粉针抗心律失常的药效学。方法采用哇巴因、氯化钙、乌头碱、氯仿诱导心律失常动物模型 ,分别观察不同剂量组的莲心碱冻干粉针抗心律失常的作用。结果高、中、低剂量的莲心碱冻干粉针均能显著提高哇巴因和乌头碱致大鼠室性早搏 (VE)、室性纤颤 (VF)及心脏停搏 (CA)时的用量 ;延长氯化钙诱发大鼠心律失常出现的时间 ,缩短生存大鼠的窦性心律恢复时间 ,减少死亡率 ;降低氯仿所致小鼠室颤发生率 ,延长小鼠出现室颤的时间。

Objective To study the antiarrhythmic effect of liensinine lyophilization. Methods Four arrhythmic animal models were performed respectively:ouabain-induced arrhythmia in guinea pigs,Cal 2 and aconitine-induced arrhythmia in rats,trichloromethane-induced arrihythmia in mice. Results With the injective dosage of high、middle and low, liensinine lyophilization could markedly increase the threshold dosage of ventricular extrasystol(VE), ventricular fibrillation(VF) and cardiac arrest(CA) caused by ouabain in guinea pigs or by aconitine in rats; delay the onset time of arrhythythmia and shorten the recovering time of normal heart rate and mortality of CA caused by CaCl 2 in rats;reduce the ratio and delay the onset time of VF caused by trichloromethane in mice. Conclusion Liensinine lyophilization has extensive antiarrhythmic effects.