4,4-二甲基异噁唑烷-3-酮的合成工艺研究

Study on Synthetic Process of 4,4-dimethyl-3-isoxazolidinone

以3 氯 N 羟基 2,2 二甲基丙酰胺为原料,在碱性条件下闭环得到4,4 二甲基异口恶唑烷 3 酮,收率达90%以上.分离出2种同分异构体,确定其比例,并对反应进行工艺条件的优化:氢氧化钠的质量分数为30%,pH值固定为9.0～10.0,反应温度为50℃,对产品结构进行1H NMR,IR,MS测定.

4,4-dimethyl-3-isoxazolidinone was synthesized by cyclization of 3-chloro-N-hyroxy-2,2-dimethylpropanamide. The overall yield was 90 %.Two isomer was separated and determined. This step's process conditions are optimized:%w%(NaOH)30 %,pH 9.0～10.0, reacting at 50 ℃. The molecular Structure of prepared product was identified by ~1H-NMR, IR, MS spectra.