乙肝疫苗接种后无、弱应答者复种后免疫效果分析

Analysis of immunizing effect for hepatitis B revaccination in non-and hypo-responders to the vaccine Ⅱ

目的对乙肝疫苗接种后无、弱应答者加强免疫后的效果进行分析。方法对接种重组(酵母)乙肝疫苗1年后无应答者31例和弱应答者21例医务人员进行加强免疫。接种剂量分为10μg重组(酵母)乙肝疫苗1针,和按0、1、6月3针常规免疫程序接种,剂量为每针10μg。接种免疫3个月后,查抗-HBs 阳性情况。结果无应答者加强1针疫苗后,抗-HBs 阳转率为38.5%,其中抗体滴度 S/N≥10仅占7.7%,按常规3针加强免疫后抗-HBs 阳转率为88.9%,抗体滴度 S/N≥10的为66.7%。两组比较有显著性差异(P<0.01)。弱应答者加强1针免疫后抗-HBs 滴度 S/N≥10为75.0%,而加强3针后抗-HBs 滴度 S/N≥10为77.8%,两组比较无显著性差异(P>0.05)。结论初免后抗-HBs 为阴性者应按0、1、6月3针常规免疫再次复种,而对于弱应答者加强1针10μg可获得保护效果。

Objective To analyze immunizing effect for hepatitis B revaccination in non-and hy- po-responders to the vaccine Ⅱ.Methods Thirty-one non-responders and 21 hypo-responders were boostered.The inoculable dosage was 10ug recombination hepatitis B vaccine.According to different in- oeulable methods,the subjects were divided into 4 groups:non-responders treated with an injection group(NAIG),non-responders treated without injection(ie,three injection) group (NATG),hypo-re- sponders treated with an injection group(HAIG)and hypo-responders treated without injection group (HATG).The seroeonversion of anti-HBs was observed at 3 month after vaccination.Results The se- roconversion rate in NAIG and NATG were respectively 38.5% and 88.9%,and the titer of antibody (S/N≥10) in NAIG and NATG were respectively 7.7% and 66.7%,and there was significant differ- ence between NAIG and NATG(P<0.01);the seroconversion rate in HAIG and HATG were respec- tively 75.0% and 77.8 %,and there was no significant difference between HAIG and HATG (P>0. 05).Conclusion After first inoculation,for acquiring protective effect,non-responders should be vac- cinated according to routine process,but an injection is boostered for hypo-responders.