腹水四项指标检测对消化系恶性腹水的诊断价值

Diagnostic Value of Combined Four Ascites Markers Detection for Malignant Ascites of Digestive System

【目的】探讨腹水肿瘤标记物对消化系恶性肿瘤所致腹水的诊断价值。【方法】用放射免疫法检测5 6例消化系肿瘤和 32例良性腹水患者的腹水标志物CEA、CA50 、CA19 9、SF。【结果】消化系恶性肿瘤患者腹水四项标记物测定值均较两对照组高 ,阳性率也较对照组高 ,且差异均有显著性 (P <0 .0 1)。四项标记物联合检测时 ,对癌性腹水的敏感性、特异性可达 83.9%、84 .3% ,诊断准确性 84 .1%。

ObjectiveTo evaluate the combined detection of 4 ascites tumor markers for diagnosis of ascites caused by malignant tumors of digestive system.The levels of carcino-embryonic antigen (CEA), CA 50, CA 19-9 and serum ferroprotein (SF) in ascites samples collected from 56 patients with cancers of digestive system and 32 patients with benign diseases (9 cases of tuberculous peritonitis and 23 cases of liver cirrhosis served as control) were detected by radioimmunoassay(RIA).The average levels of 4 tumor markers in ascites of 56 patients with malignant tumors of digestive system were much higher than those in control group, and the positive rates of ascites in malignant tumor group were also higher than in the control (P<0.01). The sensitivity, specificity and diagnostic accuracy of combined 4 markers detection were 83.9%, 84.3% and 84.1% , respectively.[Conclusion]Combined detection of four ascites tumor markers helps to make differential diagnosis of malignant ascites from benign one.