ICAM-1、Bcl-2在鼻咽癌中的表达及意义

The Significance of ICAM-1 and Bcl-2 Expressions in Nasopharyngeal Carcinoma

【目的】探讨细胞间粘附分子 1(ICAM 1)和细胞凋亡抑制基因Bcl 2在鼻咽癌组织中的表达及意义。【方法】应用免疫组化S P法 ,对 37例鼻咽低分化鳞癌和 30例鼻咽慢性炎性黏膜活检组织进行ICAM 1、Bcl 2表达蛋白产物检测。【结果】①ICAM 1在鼻咽癌组织阳性表达率 6 7.6 % ,明显高于鼻咽慢性炎性黏膜组织 6 .7% (P <0 .0 1)。②Bcl 2在鼻咽癌组织阳性表达率 83.8% ,明显高于鼻咽慢性炎性黏膜组织 10 .0 %(P<0 .0 1)。③ICAM 1、Bcl 2在鼻咽癌中的表达呈正相关。【结论】ICAM 1、Bcl 2在鼻咽癌组织中表达可能在鼻咽癌细胞的凋亡、侵袭和转移过程中起重要作用 ,两者同时高表达可能协同促进鼻咽癌的侵袭和转移。

Objective To study the expression of intercellular adhesion molecule-1 (ICAM-1) and B cell lymphoma-2 gene (Bcl-2) in tissues of nasopharyngeal carcinoma(NPC) and its significance.The expressions of ICAM-1 and Bcl-2 proteins in biopsied tissues from 30 patients with chronic nasopharyngitis(CN) and 37 patients with squamous type of low differentiated NPC were detected by streptavidin diotin peroxidase(S-P) method. ①The positive expression rate of ICAM-1 in NPC tissues was 67.6% ,significantly (6.7%)higher than that in the mucous membrane tissues of CN (P<0.01), ②The positive expression rate of Bcl-2 in NPC tissues was 83.8%, distinctly(10.0%) higher than that in the mucous membrane tissues of CN (P<0.01), ③ there was a positive correlation between the expressions of ICAM-1 and Bcl-2 in NPC.[Conclusions] Expressions of ICAM-1 and Bcl-2 in NPC tissues may play an important role in the course of NPC cell apoptosis, invasion and metastasis. The simultaneous over-expressions of both may coordinate the promotion of NPC invasion and metastasis.