2Semenza GL. HIF-1 and mechanisms of hypoxia sensing. Curr Opin Cell Biol, 201, 13(2): 167- 171
3Epstein AC, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell, 2001, 107(1): 43～54
4Zhong H, Chiles K, Feldser D, et al. Modulation of hypoxiainducible factor lalpha expression by the epidermal growth factor/phosphatidylinositol3-kinase/PTEN/AKT/FRAP pathway in human prostate ancer cellsL Implications for tumor angiogenesis and therapeutics. Cancer Res, 200, 60(6): 1541 ～ 1545
5Jeong JW, Bae MK, Ahn MY, et al.Regulation and destabilization of HIFlalpha by ARD1-mediated acetylation. Cell, 2002, 11(5): 709～720
6Fukuda R, Hirota K, Fan F, et al.Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem, 2002, 277(41): 38205～ 38211
7Brahimi-Horn C, Berra E, Pouyssegur J. Hypoxia: The tumor' s gateway to progression along the angiogenic pathway. Trends Cell Biol, 2001, 11(11 ): S32 ～ S36
8Inoue M, Itoh H, Ueda M, et al.Vascular endothelial growth factor(VEGF) expression in human coronary atherosclerotic esions: Possible pathophysiological significance of VEGF in ession of therosclerosis.Circulation, 1998, (20): 2108 ～2116
9Zhao Q, Egashira K, Inoue S, et al.Vacular endothelial growth factor is necessary in the development of arteriosclerosis by recruiting/activating monocytes in a rat model of long-term inhibition of nitric oxide synthesis.Circulation, 2002, 105(9): 1110～1115
10Gorlach A, Diebold I, Schini-Kerth VB, et al. Thrombion activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase. Circ Res,2001, 89(1): 47～54.
7Clemmensen P, Grande P, Aldrich HR, et al. Evaluation of formulas for estimating the final size of acute myocardial infarcts from quantitative ST - segment elevation on the intial standard 12 - lead [ J]. ECG J Electrocardiol, 1991,24( 1 ) :77 - 83.
