巨噬细胞与血管内皮生长因子在消化道平滑肌肿瘤中的表达及意义

Expression and its significance of vascular endothelial growth factor and macrophage in leiomyoma and leiomyosarcoma of gastrointestinal tract

目的 探讨消化道平滑肌肿瘤组织中巨噬细胞(CD68)和血管内皮生长因子(VEGF)的表达和相互关系。方法 应用SP免疫组织化学方法对74例消化道平滑肌肿瘤及22例正常组织进行CD68及VEGF的检测和分析。结果 CD68在平滑肌瘤、平滑肌肉瘤及正常平滑肌组织中的阳性率分别为82.22％、37.93％、22.73％,平滑肌瘤中的阳性表达率显著高于平滑肌肉瘤和正常组织(P<0.05);VEGF在平滑肌瘤和平滑肌肉瘤中的阳性表达率为15.56％、82.76％,平滑肌肉瘤中的阳性率显著高于平滑肌瘤(P<0.05);在平滑肌肉瘤和平滑肌瘤中VEGF和CD68的表达呈显著负相关(r s分别为-0.7292和-0.6998,P<0.05)。结论 消化道平滑肌瘤中有CD68的高表达,肉瘤中则有VEGF的高表达,与肿瘤的生物学特性有关,CD68和VEGF的表达在消化道平滑肌肿瘤中有等级相关性。

Objective To study the significance of macrophage(CD68) , vascular endothelial growth factor(VEGF) expression and their relationship in leiomyoma and leiomyosarcoma of gastrointestinal tract. Methods Immunohistochemical SP method was used to detect the expression of VEGF and macrophage in 74 tumors and 22 normal tissues. Results The positive expression rate of CD68 in leiomyoma was 82.22 % , higher than that of 37.93% in leiomyosarcoma and 22 .73 % in no-mal tissues ( P < 0 .05) . The positive expression of VEGF was 15.56% , lower than that of 82 .76 % in leiomyosarcoma ( P < 0.05). The expression of CD68 was correlated with VEGF (rs =-0.7292 and -0.6998, P < 0.05) in leiomyoma and ieiomyosarcoma. Conclusion The overexpression of CD68 was found in leiomyoma and VEGF overexpression existed in leiomyosarcoma, which have correlation with the feature of leiomyoma and leiomyosarcoma in gastrointestinal tract.