国产奥沙利铂为主的联合化疗治疗51例晚期大肠癌疗效观察

Clinical Study on Treatment of the Advanced Colon Carcinoma with (Domestic-made) Oxaliplatin

目的:观察含国产奥沙利铂(L-OHP)的联合方案治疗晚期大肠癌的临床疗效和不良反应。方法:51例晚期大肠癌患者随机分为治疗组和对照组。A组(治疗组):L-OHP130mg/m2,静滴第1天,亚叶酸钙(CF)200mg/m2,静滴第1～5天,氟脲嘧啶脱氧核苷(FUDR)400mg/m2,静滴第1～5天,21天为一个周期;B组(对照组):CF200mg/m2,静滴第1～5天,FUDR400mg/m2,静滴第1～5天,21天为一个周期。2周期后评定疗效。结果:A组26例患者有效率46.2%,不良反应主要为感觉神经毒性,恶心,呕吐和白细胞下降;B组25例患者有效率12.0%,不良反应主要为恶心、呕吐和白细胞下降,无神经毒性。结论:国产L-OHP联合CF+FUDR方案较CF+FUDR方案疗效提高,患者耐受良好,是治疗晚期大肠癌安全有效的方案。

Objective: To observe the efficacy and toxicity of Oxaliplantin in treatment of the advanced colon carcinoma. Methods: Fifity-one patients were enrolled into the study and were divided into two groups. The twenty-six patients of group A (the treatment group) were treated with Oxaliplatin 130mg/m2 on day 1, CF 200mg/m2 on day 1-5, and FUDR 400mg/m2 on day 1-5, respectively. There were 21 days in one cycle. The twenty-five patients of group 2 (the control group) were treated with CF 200mg/m2 on day 1-5 and FUDR 400mg/m2 on day 1-5 also, and there were 21 days in one cycle, too. The efficacy was evaluated two weeks after administration. Results: The efficacy of group A was 46.2%, and the main side-effects were sensory neurotoxicity, nansea, vomiting and drop of white blood cells. The effective rate in group B was 12% and the side-effects were nausea and vomiting, without neurotoxicity. Conclusion: The efficacy of the Oxaliplatin combined with the CF and FUDR in treatment of the advanced colon cancer was better than that of CF and FUDR. only. The patients can tolerate the side-effects well, so it's feasible in clinical treatment.