小剂量尿激酶溶栓治疗老年高龄急性心肌梗死65例临床观察

Analysis of Curative Effect on Treatment of 31 Cases the Aged AMI with Small Dosage of Urokinase Thrombolysis

目的 尝试用小剂量尿激酶治疗老年高龄急性心肌梗死 ,旨在使老年高龄患者亦从溶栓治疗中获益。方法 采用WHO关于急性心肌梗死 (AMI)的诊断标准 ,收治老年高龄患者 6 5例。随机分为两组 ,溶栓组 31例 ,给予小剂量尿激酶 (5 0×10 4U) 30min静脉滴入 ;并与非溶栓组 34例对照观察。结果 溶栓组冠脉再通率、五周病死率、休克、心衰分别为 5 4 .8%、6 4 %、3.2 %、9.7% ;而对照组分别为 14 .7%、2 3.5 %、2 6 .5 % :4 1.2 % ,有明显差异 (P <0 .0 1)。结论 有条件的基层医院依然有可能实施小剂量尿激酶对老年高龄患者的溶栓治疗 ,且可挽救更多老年高龄患者的生命。

Objective To treat the aged acute myocardial infarction with small dosage of urokinase so that the aged patients can prolong life by thrombolysis. Method Adopting AMI diagnose standard by WHO, 65 cases of the aged patients were admitted and divided into 2 groups. 31 cases in the first group were given 30 minutes intravenous injection with small dosage of urokinase (50 ×104U)and compared with 34 cases of non-urokinase group.Result The rate of re-free coronary artery circulation in thrombolysis group and death in 5 weeks,shock and heat failure were 54.8%,6.4%,3.2%,9.6% respctively,while in the compared group were 14.7%,23.5%,26.5%,41.2% respectively. Conclusion Primary hospitals with basic equipments may use small dosage of urokinase to treat aged patients contracting AMI for thrombolysis, so as to save more lives of the aged patients.