伴有2型糖尿病的冠心病患者血中C反应蛋白的变化

C-reactive Protein is elevated in Coronary Artery Disease Patients with Type 2 Diabetes Mellitus

目的 了解伴有 2型糖尿病的冠心病患者血中C反应蛋白 (CRP)的变化 ,探讨糖尿病对CRP的影响。方法 采用酶联免疫法对经冠状动脉造影证实的慢性稳定性心绞痛患者测定血清CRP ,其中伴有 2型糖尿病 (DM)患者 5 3例 ,无糖尿病患者 38例。结果 在冠心病患者中 ,DM较无DM者CRP显著增高 ;而且冠心病患者中DM合并陈旧性心梗者的CRP亦较无DM的陈旧性心梗者显著增高 ;单因素回归分析示CRP与血总胆固醇、低密度脂蛋白和甘油三酯水平显著正相关 ,而与HDL显著负相关。结论 CRP在糖尿病合并冠心病患者血中更显著增高 ,提示炎症反应在糖尿病致动脉粥样硬化形成中起重要作用。

Objective To investigate C-reactive protein level in coronary heart disease patients with type 2 diabetes mellitus compared with those without diabetes. Methods 53 coronary heart disease patients with type 2 diabetes mellitus and 38 without diabetes were measured serum CRP by enzyme-linked immunoabsorbent assay. All the patients were documented by angiogram. Results C-reactive protein was significantly increased in coronary artery disease patients with diabetes compared with those without diabetes (2.95±2.42mg/L vs 1.23±0.95mg/L; P<0.01). Moreover, CRP level in diabetic patients with previous myocardial infarction increased significantly compared with those previous myocardial infarction patients without diabetes (3.35±2.24mg/L vs 1.21±1.15 mg/L; P<0.01). Univariate analysis implied that CRP levels were positively associated with serum total cholesterol, LDL cholesterol, triglyceride, and negatively associated with high density lipoprotein cholesterol. Conclusion CRP level was significantly elevated in coronary artery disease patients with type 2 diabetes, which implied that inflammation might play an important role in the coronary artery disease with diabetes, and diabetes promotes atherosclerosis.