转录因子诱杀性寡聚核苷酸抑制NF-κB基因治疗的研究
Gene therapy of NE-kappaB decoy oligodeoxynucleotides
摘要
核因子 κB(NF κB)是一种很重要的转录因子 ,其过度表达与许多疾病的免疫病理机制有关。国内外有关以NF κB为靶点的拮抗治疗策略很多 ,目前针对NF κB基因治疗已经成为非常有吸引力的治疗方法。近年的研究发现 ,诱杀性寡聚核苷酸抑制NF κB靶性基因治疗利用外源性含有转录因子结合序列的寡聚核苷酸来操纵转录因子和其他调节因子的基因表达 ,达到治疗疾病的目的 ,在实验中取得了一些可喜成果 ,但有局限性 ,临床应用尚需进一步研究。
出处
《国外医学（麻醉学与复苏分册）》
2004年第6期374-376,共3页
Foreign Medical Sciences(Anesthesilolgy and Resuscitation)
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