急性心肌梗塞患者凝血与纤溶状态的研究

Study of Coagulation and Fibrinolysis in the Patients with Acute Myocardial Infraction

本文检测19例急性心肌梗塞(AMI)患者多项凝血、抗凝及纤溶指标,并与29例年龄相近之健康对照进行比较研究。检查发现 AMI 患者凝血酶-抗凝血酶复合物、抗凝血酶Ⅲ及纤维蛋白原显著增高(P<0.05),因子 X(Fx)呈双向性变化,血纤维蛋白降解产物、血浆素原活化素抑制物显著增高(P<0.01),血栓弹力图明显异常(56.3%)。而许多常规指标的变化与对照无显著差异。对6例AMI 患者进行上述指标动态观察,发现了时限性的变化规律。研究提示,AMI 存在多项凝血、抗凝及纤溶异常,这些检测对患者的诊断、治疗及预后具有一定意义。

In 19 patients with acute myocardial infarction(AMI),various parameters ofcoagulation,anticoagulation as well as fibrinolysis were determined,as compared with thosein 29 healthy controls of the same age.It was found that in patients with AMI significantlyhigher levels of thrombin-antithrombinⅢ(TAT)complexes,antithrombinⅢ(AT-Ⅲ) andfibrinogen were noted,Factor X changed in double-direction,plasminogen activator inhibitor(PAI)had a significantly higher level,and thromboelastogram(TEG)was significantly ab-normal(56.3%).In contrast,changes in many routine parameters were not significantlydifferent from those in the controls.The above parameters were dynamically observed in 6patients with AMI,indicating that variability was time-dependent.Our experimental resultssuggest that in patients with AMI abnormal parameters were observed in the coagulant,an-ticoagulant and fibrinolytie system.All of which may play a important role in the diagnosis,treatment and prognosis of AMI