当归等对博莱霉素致鼠肺损伤和脂质过氧化物生成的影响

Effect of Radix Angelicae Sinensis and Radix Salvia Miltiorrhizae on BLM-induced Lung Injury and lipid Peroxidation in Rats

利用博莱霉素致大鼠肺损伤模型,观察了当归、丹参及消炎痛对博莱霉素致肺损伤的病理改变、血清脂质过氧化物含量和肺湿重/体重的变化。结果发现,当归和丹参可明显减轻肺泡炎的严重程度,降低肺湿重/体重(P<0.01),并可抑制脂质过氧化物的产生(P<0.01),消炎痛则无上述作用。表明当归和丹参可阻抑博莱霉素引起的急性肺损伤,作用机理可能是两药对自由基的清除作用。

A model of pulmonary alveolitis in rats has been developed using intratra-cheal administration of bleomycin (BLM) A5 (5 mg/kg). The effects of Radix Angelicae Sinensis (RAS), Radix Salviae Mihiorrhizae (RSN) and indomethacin in BLM-induced pulmonary alveolitis were studied. We found that RAS and RSN could reduce BLM-induced alveolitis, decrease lung wet wt/body wt (P<0. 01), and inhibit the production of serum MDA (P<0. 01), but indomethacin could not do so. Our results indicated that RAS and RSM possess some protective role in BLM-induced pulmonary injury. A possible mechanism lies in that RAS and RSM are free radical scavengers.