流行性出血热特异性循环免疫复合物检测及其临床意义

Clinical Significance of Epidemic Hemorrhagic Fever Specific Circulating Immune Complexes

对263份不同病期流行性出血热患者血清中特异性循环免疫复合物进行了检测,同时观察了体液免疫功能、补体及纤维连结蛋白的动态变化,并应用放射免疫分析法测定了患者血浆β_2-微球蛋白与Tamm-Horsfall蛋白及尿液中β_2-微球蛋白含量。实验结果表明,流行性出血热患者体内可检出特异性IgG型、IgM型、IgA型、IgE型及IgD型循环免疫复合物,虽然它们的消长趋势有所不同,但是皆与流行性出血热患者补体激活、肾功能损伤及临床过程有密切关系,表明由特异性循环免疫复合物所介导的Ⅲ型变态反应是构成流行性出血热发病机理的重要因素。

Virus antigen specific circulating immune complexes have been detected in 263 sera samples of patients with epidemic hemorrhagic fever. Immunoglobulins, complement components, fibronectin, β2-microglobulin and Tamm-Horsfal protein in the samples collected in different clinical phases of these patients have also been investigated. Our experimental results showed that there are five types of the specific circulating immune complexes, i. e. IgG, IgM, IgA, IgE, IgD types, in sera of the patients and the dynamic changes of the specific circulating immune complexes are different. Close correlations have been found between the specific circulating immune complexes and the activation of complements, impairment of renal function and the clinical manifestations of the patients. From the above it is reasonable to assume that the third type allergy reaction may play an important role in the pathogenesis of epidemic hemorrhagic fever.