N-cadherin、MMP-9在直肠癌中表达的临床意义

Studies on the Clinical Significance of N-cadherin、MMP-9 in Rectal Cancer

目的 探讨 N-钙黏附素(N-cadherin)、基质金属蛋白酶-9(MMP-9)在直肠癌中表达的临床意义。方法 采用免疫组织化学两步法对 80 例直肠癌组织中的 N-cadherin、MMP-9 表达进行检测。结果 (1)N-cadherin在直肠癌组织中的阳性表达率为41.25%,其中 A、B期患者和 C、D期患者分别为28.9%和57.1%(P<0.05);淋巴结转移组和无淋巴结转移组分别为58.6%和31.4%(P<0.05);肝转移组和无肝转移组阳性表达率分别为69.2%,35.8%( P<0.05) 。(2) MMP-9在直肠癌组织中的阳性表达率为60%,其中A、B期患者和C、D期患者阳性表达率分别为40%,85.7%(P<0.01);淋巴结转移组和无淋巴结转移组阳性表达分别为82.8%,47.1%(P<0.01),发生肝转移组和无肝转移组阳性表达率分别为84.6%,55.2%(P<0.05)。( 3)Kaplan Meier分析,N-cadherin、MMP-9 阳性表达者的生存时间和5年生存率明显低于N cadherin、MMP-9阴性表达者(P<0.01)。结论 N-cadherin、MMP-9 的表达与直肠癌关系密切,对判断其预后可能具有重要意义。

Objective Studies on the clinical significance of N-cadherin、MMP-9 in Rectal Cancer.Methods The expression of N-cadherin、MMP-9 of 80 cases of rectal cancer were studied with immunohistochemical two steps technique.Results (1)The expressive rate of N-cadherin of Rectal Cancer was (41.25%).The expression of A-B grade and C-D grade were (28.9%) and (57.1%) respectively(P<(0.05)) . The expression of lymph node metastasis and no lymph node metastasis were (58.6%) and (31.4%) respectively (P<(0.05)); The expression of liver metastasis and no liver metastasis were (69.2%) and (35.8%) respectively(P<(0.05)). (2) The expressive rate of MMP-9 of Rectal Cancer was 60%. The expression of A-B grade and C-D grade were 40% and (85.7%) respectively (P<(0.01)) ;The expression of lymph node metastasis and no lymph node metastasis were (82.8%) and (47.1%) respectively; The expression of liver metastasis and no liver metastasis were (84.6%) and (55.2%) respectively (P<(0.05)). (3) The mean survival time and 5-year survival rate in cases with positive N-cadherin and MMP-9 expression were significantly shorter than that of cases with negative expression.Conclusion The expression of N-cadherin、MMP-9 was closely related to the rectal cancer , and would be a valuable prognostic marker.