献血员血清β_2-微球蛋白的放射免疫测定

RADIOIMMUNOASSAY OF SERUM β_2-MICROGLOBULIN IN DONOR'S BLOOD

对149例献血员和54例正常人血清进行了β_2-微球蛋白(简称β_2-MG,下同)的放射免疫测定,其结果分别为:203±33.0 nmol/l、176±26.2 nmol/l,经统计学处理二者之间有显著差异(P<0.001),结果表明:献血史越长或献血时间间隔越短,其血清β_2-MG的含量升高越明显,为了提高用血质量,保证献血员的身体健康,建议用血清β_2-MG含量的升高作为其频繁献血的指标。结果还表明,不宜采用献血员血清β_2-MG含量作为正常参考值。

Serum β_2-microglobulin (β_2-MG) was tested by radioimmunoassay in 149 donors' and 54 healthy volunteers' blood. The results were 203±33.0 nmol/1 and 176 ± 26.2 nmol/1, respectively. There was significant difference statistically between them (P<0.001). The results showed that the longer the history of blood donor or the shorter the interval of blood donating, the higher the β_2-MG content. In order to increase the quality of donated blood and to keep the health of blood donor, it is suggested that the high content of serum β_2-MG be the indicator of too frequent blood donating. The results also showed that the content of β_2-MG in donor's blood is not a normal reference value.