摘要
目的 探讨危重病患者肿瘤坏死因子α(TNF α)、白细胞介素 6(IL 6)、白细胞介素 8(IL 8)、可溶性白细胞介素 2受体 (sIL 2R)检测APACHEⅡ评分的临床意义。 方法 对 46例危重病患者检测TNF α、IL 6、IL 8、sIL 2R值 ,同时进行APACHEⅡ评分。 结果 危重病患者TNF α、IL 6、IL 8、sIL 2R较正常对照组明显升高 ,MODS组较非MODS组升高更明显 ,死亡组与存活组相比 ,TNF α、IL 6、IL 8、sIL 2R均明显升高 ,APACHEⅡ评分 >2 5分者TNF α、IL 6、IL 8、sIL 2R较评分 <15分者明显升高 ,有显著差异 ;较评分 15~ 2 5者升高 ,但差异无显著性 ,相关性分析显示 :APACHEⅡ与TNF α、IL 6、sIL 2R明显正相关。 结论 危重病患者细胞因子检测可反映病情 。
Objective To explore the clinical significance of plasma tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), interleukin-8(IL-8) and soluble interleukin-2 receptor(sIL-2R) in APACHEⅡ scores of critical patients. Methods Plasma TNF-α, IL-6, IL-8, sIL-2R levels and APACHEⅡ scores were measured in 46 critical patients. Results The plasma levels of TNF-α, IL-6, IL-8 and sIL-2R were significantly higher in critical patients ,especially in MODS group than those of healthy controls. The plasma levels of TNF-α, IL-6 and sIL-2R were significantly higher in nonsurvivor than those of survivor. The plasma levels of TNF-α, IL-6, IL-8 and sIL-2R were obvious correlative with APACHEⅡ scores. Conclusion The measurement of plasma levels of TNF-α, IL-6, IL-8 and sIL-2R could reflect critical patients'ill condition and predict their prognosis.
出处
《浙江临床医学》
2005年第1期17-18,共2页
Zhejiang Clinical Medical Journal