文拉法新与马普替林及丁螺环酮治疗抑郁症的对照研究

A comparative study of Venlafaxine,Maprotiline and Buspirone in the Treatment of Depression.

目的 比较文拉法新与马普替林及丁螺环酮治疗抑郁症的效果。方法 随机将抑郁症病人分为 3组。A组为文拉法新治疗组 ( 3 1例 ) ,B组为马普替林治疗组 ( 3 2例 ) ,C组为丁螺环酮治疗组 ( 3 0例 )。 3组均采用中等药物剂量及增量法。以CGI-I、HAMD、HAMA3种量表观察 6周的疗效 ,并以 TESS观察其副反应。结果 6周后 3组 HAMD减分率分别为 0 .68± 0 .1 5 ,0 .5 7± 0 .2 6,0 .5 1± 1 .1 ,无显著差异 ( P>0 .0 5 ) ,但 A组与 C组在治疗第 2周末减分率分别为 0 .3 1± 0 .2 5 ,0 .0 5±2 .1 ( t=2 .82 ,P<0 .0 5 )有显著差异。3组 HAMA减分率分别为 0 .77± 0 .1 2 ,0 .48± 0 .1 5 ,0 .8± 1 .2 ,故 A组与 C组无显著差异 ( P>0 .0 5 ) ,但 A组与 C组显著优于 B组 ( P<0 .0 5 )。TESS测 6周末加分率 ,3组分别为 3 7.2 1 % ,73 .61 % ,3 4.3 2 %。即 A组与 C组无显著差异 ( t=0 .42 ,P>0 .0 5 ) ,但 B组显著高于 A组 ( t=2 .2 8,P<0 .0 5 )及 C组 ( t=3 .2 1 ,P<0 .0 5 )。结论 文拉法新优于马普替林、丁螺环酮抗抑郁、抗焦虑疗效 。

Objective To evaluate the efficacy of venlafaxine,maprotiline and buspirone in the treatment of depression. Methods 93 patients of depression were randomly divided into 3 groups.In Venlafaxine group(group A) were treated with Venlafaxine 125mg/d,P.O for 6 weeks.Maprotiline group(group B) were treated with Maprotiline 125mg/d for 6 weeks.and Buspirone group(group C) were treated with Buspirone 30mg/d for 6 weeks.HAMD,HAMA and TESS were used to evaluate symptoms and effects and side effects for 6 weeks. Results For patients completing 6 weeks of treatment with Venlafaxine. the HAMD total scare impraved by 0.68±0.15 points.Improvement at 6 weeks was 0.57±0.26 points for patients treated with Maprotiline,and improvement at 6 weeks was 0.51±1.1 points for patents treated with Buspirone (P>0.05).But at 2 weeks,the marked effective rate of Venlafaxine group and buspirone group was 0.31±0.25 and 0.05±0.21.respectively in treating depression symptoms(P<0.05) For patients compleliny 6 weeks of treatment with Venlafaxine.The HAMA total score improved by 0.77±0.12 points.Improvement at 6 weeks was 0.80±1.2 points for patients treated with Buspirone (P>0.05).However on HAMA, the effective rates was significant difference between Venlafaxine and Buspirone, Maprotiline (0.48±0.15)(P<0.05) .The increase of scores of TESS was significantly lower in Venlafaxine group,Buspirone group then in Maprotiline group,the increase of scorea of TESS was 37.21,73.60,34.32 in three groups.Conclusion Venlafaxine has antidepressant efficacy was the same as Maprotiline and batter then Buspirone,Venlafaxine has same anti-anxiety efficacy as Buspirone.Venlafaxine was superior in anti-anxiety efficacy to Maprotiline.The safety profit of Venlafaxine was possibly better then Maprotiline.