胃癌、大肠癌组织中p27蛋白的表达及其意义

EXPRESSION AND IMPLICATION OF p27 IN GASTROINTESTINAL CANCER

目的 探讨p2 7蛋白在胃癌及大肠癌组织中的表达及其与临床病理学特征的关系。方法 采用免疫组化方法对3 4例正常大肠组织、2 1例胃癌组织及 3 8例大肠癌组织 p2 7的表达及其与临床病理学特征的关系进行分析。 结果 p2 7在正常结肠组织中的高表达率为 10 0 % (3 4/3 4) ,而在胃癌及大肠癌组织中的高表达率为 5 2 5 % (3 1/5 9) ,p2 7在两组织中的表达差异有显著性 (P <0 0 0 5 ) ,而且p2 7低表达与胃癌及大肠癌的分级高、淋巴结转移多与TNM分期晚显著相关。结论 p2 7蛋白的表达与胃癌、大肠癌的临床病理学特征密切相关 ,可能是一个预测胃癌、大肠癌预后的重要指标。

Objective To investigate the relationship between the expr es sin of p27 and clinicopathologyical characteristics in gastrointestinal cancer. Methods 34 cases of normal colorectal tissues and 59 cases of gastrointestinal adenocarcinoma(21 cases of gastric,38 cases of colorectal aden ocarcinoma) were studied by immunohistochemistry. Results p27 high expression rate for normal tissues was 100%, but for gastrointestinal carc inoma was 52.5%(31/59) (P<0.005). p27 low expression in gastrointestinal carcinoma was significantly associated with high?grede histology (P<0.005 ), lymph node metastasis (P<0.005) and late TNM stage (P<0.005).Conclusions The expression of p27 in gastrointestiportant factor to predict the prognosis of gastrointestinal cancer.