摘要
90％以上的肿瘤是由各种环境因素与职业因素引起,而大部分的外源性致癌物需经过Ⅰ相和Ⅱ相代谢酶的代谢活化才与体内生物大分子作用启动致癌过程。细胞色素P4502E1(cytochromeP450s2E1,CYP2E1)是人体内重要的Ⅰ相代谢酶类,参与N-亚硝胺类化合物等多种前致癌物的代谢活化过程,在体内各组织器官中有不同的表达。CYP2E1活性的表达受多种因素影响,存在多种限制性片段长度多态性,与人类肿瘤易感性间存在密切关系。
Up to 90% of all cancers are possibly caused by environmental and occupational factors.The majority of chemical carcinogens require metabolic activation before they interact with cellular macromolecules and cause cancer initiation. The xenobioticmetaboliain machinery contains two main types of enzymes: phase Ⅰ and phase Ⅱ metabolism enzymes. Cytochrome P450 2El(CYP2El)is a significant phase I metabolism enzyme in vivo. It plays an important role in metabolic activation of carcinogenic nitrosamines,benzene and low molecular weight halogenated hydrocarbons,etc. It was reported that CYP2E1 shows RLFP polymorphisms and expresses differently in each organ. It has been suggested to contribute to individual cancer susceptibility as genetic risk of cancer factor.This is a review on the recent studies in this field.
出处
《环境与职业医学》
CAS
北大核心
2004年第6期476-479,共4页
Journal of Environmental and Occupational Medicine
基金
东南大学科技基金项目(编号:XJ019004)
