180例不孕妇女抗精子抗体测定结果分析

The Analysis of AsAb from 180 Infertile Females

目的 探讨不孕妇女血清和宫颈粘液中AsAb与不孕的关系。方法 采用酶联免疫吸附试验(ELISA) ,分别测定每一研究对象血清及宫颈粘液中的AsAb。结果 血清与宫颈粘液AsAb的总阳性率分别为 13.9%、2 5.0 % ,两者具有显著差异 (χ2 =7.0 9,P <0 .0 1)。宫颈粘液中AsAbIgA(19.4 % )明显高于IgG(7.8% )及IgM(5.0 % ) ,且具有显著意义 (χ2 =10 .4 2 ,χ2 =17.50 ,P <0 .0 1) ,说明以IgA为主 ,IgA与IgG、IgM之间缺乏相关性。血清AsAbIgA、IgG、IgM分别为 3.9%、8.3%、7.2 % ,其中 ,以IgG为主。

Objective: To investigate the relationship between infertility and Antisperm Antibody(AsAb) in serum and cervical mucus in infertile females. Methods: AsAb from 180 infertile females were determined by means of Enzyme Linked Immunoabsorbent Assay(ELISA).Results: The total positive rates of AsAb in serum and cervical mucus were 13.9% and 25. 0 % respectively.The positive rate in cervical mucus was significantly higher than that in serum(χ 2=7.09,P<0.01). Furthermore, in cervical mucus,there was also significant difference between IgA(19.4%)and IgG(7.8%),IgA and IgM(5.0%).Suggesting that IgA of AsAb predominated and IgA was not associated with IgG and IgM. Among AsAbs,IgA,IgG and IgM were 3.9%, 8. 3 % and 7. 2 % respectively. Conclusion: AsAb may decrease the ability of fertility in women.