C-反应蛋白对不稳定型心绞痛患者发生心血管并发症的预防及药物干预

Correlation between C-reactive protein and the prognosis of patient with unstable angina pectoris and the effect of drug intervention

目的 研究C 反应蛋白 (CRP)升高与不稳定型心绞痛 (UA)患者的预后关系及用氟伐他汀干预后的结果。方法 将 170例不稳定性心绞痛患者中CRP <4.0mg L的作为A组 ,将CRP >4.0mg L的分为B、C两组 ,C组给予氟伐他汀 40mg每晚 1次干预治疗。结果 A组 60例患者中发生急性心肌梗死 3例 ,无死亡 ;B组 5 8例患者中发生急性心肌梗死 16例 ,死亡 3例 ;C组 5 2例患者中发生急性心肌梗死 9例 ,死亡 2例。A、B两组比较差异非常显著 (P <0 .0 1) ,B、C两组比较差异有显著性 (P <0 .0 5 )。结论 血清CRP是炎症反应的指标 ,炎症反应在冠状动脉粥样硬化形成中起重要作用。CRP可以判断冠心病的严重程度 ,预测是否会出现急性心血管并发症 ,是冠心病形成的独立危险因子。在UA患者中早期使用氟伐他汀可减少斑块炎症 ,加强斑块的稳定性 ,防止新的粥样斑块形成 。

Objective To investigate the correlation between C-reactive protein (CRP) and the prognosis of patient with unstable angina pectoris(UA) and the effect of drug intervention with fluvastatin.Methods 170 patients with UA were divided into three group, group A:CRP<4.0 mg/L,group B and C:CRP>4.0 mg/L.The patients in group C were given fluvastatin 40mg once a day in the evening.Results In group A,3 of 60 patients occurred acute myocardial infarction (AML),none died;in group B 16 of 58 patients occurred AMI,3 cases died; in group C,9 of 52 patients occurred AMI,2 cases died.There was a significant difference between group A and group B (P<0.01) and between group B and group C (P<0.05).Conclusion CRP is a marker of inflammation reaction,inflammation reaction plays an important role in the formation of atherosclerosis.CRP can judge the serious degree of coronary heart disease and calculate the occurrence of acute cardiovascular complication,which is an independent risk factor for the genesis of coronary heart disease.The early administration with fluvastatin for UA patients can reduce spot inflammation,strengthen the steadiness of spot,prevent the formation of new atherosclerosis and reduce the occurrence of complication of acute cardiovascular disease.