房颤患者左房大小与血管性假血友病因子、D-二聚体及红细胞压积相关性

Study of correlation between size of left atrial and plasma levels of von Willebrand factor, D-Dimer and haematocrit with chronic fibrillation

目的 探讨房颤患者左房大小(LA)与血管性假血友病因子(vWF)、D 二聚体 (D Dimer)及红细胞压积 (Hct)三项血清学指标相关性及其临床意义。方法 对我院 60例房颤住院患者进行研究。心脏超声心动图测定LA大小,同时检测vWF、D Dimer及Hct三项血清学指标。结果 房颤患者LA≥ 4 5cm组较LA<4 5cm组的vWF、D Dimer以及Hct指标明显增加 (P<0 01 ),LA大小与vWF、D DimerHct三项血清学指标明显正相关。LA大小与Hct、vWF的相关性较大(r=0 866,P<0 01;r=0 822,P<0 01),而LA大小与D Dimer指标相关性较小(r=0 523,P<0 01),两组相比差异均有显著性。结论 房颤患者左房越大则血液的凝固性越高,发生血栓的可能性就越大。

Objective To investigate the correlation and clinical significance between size of left atrial and plasma levels of von Willebrand factor, D Dimer and haematocrit in our hospital. Methods Sixty patients with chronic fibrillation[31 men and 29 women;mean age (62 5±7 46) years]were evaluated. The patients with chronic fibrillation were scrutinized size of left atrial and correlation between size of left atrial and plasma levels of von Willebrand factor, D Dimer and haematocrit in my hospital. Results The patients with chronic fibrillation in the group of left atrial≥4 5 cm in the 30 patiences was significantly higher than that of the group of left atrial≥4 5 cm in the 30 patiences on plasma levels of von Willebrand factor, D Dimer and haematocrit ( P <0 01). von Willebrand factor and haematocrit correlated significantly with left atrial may be more important than D Dimer correlated with left atrial( r =0 866, P <0 01; r =0 822, P <0 01; r =0 523, P <0 01).Conclusion The larger is left atrial, and the higher is solidification. The more feasible was thrombus.