血管内皮细胞生长因子与冠心病侧支循环的关系

Correlation between vascular endothelial growth factor and branch cycle of coronary heart disease

目的:探讨血管内反细胞生长因子(VEGF)与冠心病侧支循环情况的关系。方法:采用酶联免疫吸附试验(ELISA)检测20例无侧支循环的冠心病患者(A组)、17例有侧支循环的冠心病患者(B组)及20例正常对照组(C组)血清VEGF浓度。结果:B组血清VEGF水平明显高于A组及正常对照组(P均<0.01),A组VEGF水平亦高于正常对照组(P<0.05)。结论:有侧支循环的冠心病患者血清VEGF浓度明显升高,VEGF可能参与了冠心病侧支循环的形成。

Objective: To investigate the correlation between level of vascular endothelial growth factor (VEGF) and branch cycle in patients with coronary artery disease (CAD). Methods: Serum VEGF was measured by enzyme-linked immunosorbent assay in 20 CAD patients with no branch cycle (group A), 17 CAD patients with branch cycle (group B) and 20 normal persons (group C). Results: The level of VEGF was significantly elevated in group B as compared with group A and group C (P<0. 01). The level of VGEF in group A was higher than that of group C (P<0. 05). Conclusion : The level of serum VEGF is elevated in CAD patients with branch cycle, which may be related to the establishment of branch cycle.