S100B蛋白与颅脑损伤预后的关系

Relationship between Change in S100B Protein and Prognosis of Patients with craniocerebral Injury

目的研究血清和脑脊液中S100B蛋白含量与颅脑损伤预后的关系。方法用ELISA法测定125例急性颅脑损伤患者在伤后不同时间血清和脑脊液中S100B蛋白含量,结合GOS评分进行分析。结果伤后早期(24h内)血清中S100B蛋白含量均较对照组明显升高(P<0.01),在不同预后患者中S100B水平差异有显著意义(P<0.01)。脑脊液和血清中S100B变化趋势一致结论颅脑损伤后脑脊液和血清中。S100B蛋白均与患者预后密切相关,血清中S100B检测具有更大的临床应用价值。

Objective To study the relationship between the content of S100B protein in the serum and cerebrospinal fluid (CSF) and prognosis of patients with craniocerebral injury. Methods The serum and CSF levels of S100B protein in 125 patients were determined at the different times after craniocerebral injury by ELISA. The curative outcome was estimated according to GOS. Results The serum S100B level was significantly higher 1 day after the injury in the patients with craniocerebral injury than that in the control patients (P<0.01). There was significant difference (P<0.01) in the serum S100B levels 1 day after the injury among the three groups with different outcome (P<0.01). The change in the CSF S100B levels was similar to than in the serum S100B levels. Conclusions Both the serum and CSF S100B protein levels are closely associated with the outcome in the patients with craniocerebral injury. The serum S100B may be more clinically useful for making the prognosis of the patients with craniocerebral injury.