非小细胞肺癌纵膈淋巴结影像学分期的研究

Evaluation of imaging mediastinum lymph node staging of non-small cell lung cancer

目的:评估常见影像学检查对NSCLC纵膈淋巴结分期的准确性及价值。方法:56例经手术和病理检查确诊 的NSCLC,术前患者经胸部CT扫描、全身18F -FDGPET显像和经食管超声检查,并对手术病理结果进行回顾性的分析。结果: 所有56例NSCLC患者肺部及相应转移部位18F- FDG摄取增高,PET检查对预测NSCLC纵膈淋巴结转移的灵敏度为84%,特 异性为90%,CT扫描纵膈淋巴结转移的灵敏度为57%,特异性为82%,其中38例行经食管超声解剖显像纵膈淋巴结转移的 灵敏度为76%,特异性为70%。PET对NSCLC纵膈淋巴结转移的预测优于胸部CT解剖显像和经食管超声解剖显像。结论: 应用18F- FDGPET在对NSCLC的术前分期明显优于CT和经食管超声等常规检查,但PET在精确定位方面仍然需要结合解剖 显像检查,PET CT等图像融合技术等是今后发展的方向。

Objective:To determine the performance characteristics of CT scanning, positron emission tomography(PET) scanning, endoscopic ultrasound(EUS) for staging the mediastinum of the patients whom the non-small cell lung cancer (NSCLC) was diagnosed with pathology. Methods:Evaluating the staging results of CT scanning, PET scanning, or EUS in 56 NSCLC patients with pathologic confirmation. Results:The sensitivities and specificities for staging the mediastinum were as follows: for CT scanning: sensitivity, 57%; specificity, 82%; for PET scanning: sensitivity, 84%;specificity, 90%; and for EUS sensitivity, 76%; specificity, 70%. Conclusion:PET scanning is more accurate than CT scanning or EUS for detecting mediastinal metastases of NSCLC.