身体质量指数及腰臀围比与胆道癌关系的探讨

Body Mass Index (BMI), waist to hip ratio (WHR) and risk of biliary tract cancers: A population-based Case-control Study in Shanghai

目的:探讨身体质量指数(BMI)、腰臀围比(WHR)与胆道癌的关系。方法:采用非条件logistic回归模型分析身体质量指数、腰臀围比与胆道癌的关系。结果:与正常BMI组比较,胆囊癌女性20～29岁、30～39岁肥胖组的OR与趋势检验均达到或接近显著水平。与腰臀围比四分位最低组比较,胆囊癌和肝外胆管癌男女性最高四分位组OR和趋势检验均达到显著水平。结论:青年时期肥胖可能会增加胆囊癌的发病风险;腰臀围比也是胆囊癌和肝外胆管癌独立的危险因素。

Objective: To investigate the relationship between the body mass index (BMI), the waist to hip ratio (WHR) and the biliary tract cancers. Methods: Unconditional logistic regression was used to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Results: Obesity was associated with increased risk of gallbladder cancer across adulthood for being obese at ages 20~29 and 30~39 among females. Compared to the subjects with the lowest quartile of WHR, ORs for highest quartile and P for trend both reached significant level among males and females. Conclusion: Our observations in urban Shanghai suggest that obesity in early adult life, may contribute to the risk of gallbladder cancer. And increased WHR may substantially elevated risk of cancers of the gallbladder and extrahepatic bile duct as well.